MilbemycinMilbemycin oxime (Interceptor?? & Sentinel?? from Novartis) has benefits, which are similar to ivermectin.SelamectinSelamectin (Revolution?? by Pfizer) is applied topically to prevent heartworm disease.
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The onset and severity of disease in the dog is principally a manifestation of the amount of mature heartworms present, the era of the infection and the level of action of their dog. Dogs with high numbers of worms are generally found to have more severe heart and lung disease changes. Until the number of mature heartworms exceeds 50 at a 25-kg dog (approximately 55 pounds), almost every one of the heartworms live in the lower caudal pulmonary arteries (the blood vessels of the lower lung lobes). Greater numbers of heartworms lead to their own existence in the right chambers of the heart. In such ailments, the most common early pathological changes caused by heartworms are due to inflammatory processes that exist in and around the blood vessels of the lower part of the lungs in response to the presence of heartworms. Later, the heart may enlarge and eventually become diminished because of an increased workload and congestive heart failure may occur. An extremely active puppy (e.g., working puppy ) is far more likely to develop severe disease with a comparatively small number of heartworms compared to an inactive one (e.g., a lap dog or couch potato). Occasionally, a dog having a large number of heartworms may not only have worms at the heart, but also in the caudal vena cava (large main vein of the body) between the liver and the center. If the heartworms are not removed surgically, this syndrome causes abrupt collapse and death within two to three days.Canine heartworm disease is broadly distributed throughout the United States. Heartworm infection has been found in dogs indigenous to all 50 states. All dogs, regardless of their age, gender, or habitat, are susceptible to heartworm infection. The maximum infection rates (around 45%) in puppies (not maintained on heartworm preventative ) are observed in 150 kilometers of the Atlantic and Gulf coasts from the Gulf of Mexico into New Jersey and along the Mississippi River and its major tributaries. Other areas of the United States might have lower incidence rates (5% or less) of canine heartworm disease, though some areas have ecological, mosquito population and dog population variables that allow a greater neighborhood incidence of heartworm disease. Regions where heartworm disease is common have diagnosed illnesses in puppies as young as one year old, with most areas diagnosing infections primarily between the ages of eight and three years. Although there are differences in frequency of disease for a variety of groups of dogs, all dogs in all areas should be considered in danger, placed on prevention programs and also often examined by a vet.
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